adenosine deaminase level as an indicator for differentiating between active pulmonary tuberculosis infection and other pulmonary infections
نویسندگان
چکیده
background in spite of recent advents, and novel improvements in the diagnosis and treatment of pulmonary tuberculosis (tb), definitive diagnosis of pulmonary tb in children is problematic. therefore, measurement of the serum level of adenosine deaminase (ada) was later introduced as a helpful marker for the diagnosis of tb. objectives the purpose of this study was to determine the usefulness of the ada testin the diagnosis of pulmonary tb, and compare enzyme activity between patients with pulmonary tb and those with other pulmonary infections. the sampling strategy was randomized, and the design of study was case-control diagnostic descriptive, we used ibm spss v-16.0.2 software for analyzing our data. patients and methods this study was performed at the national research institute of tuberculosis and lung diseases (nritld) in tehran, ir iran. in all, 49 children, divided into 3 groups, were examined. of these, 22 had pulmonary tb, 17 had other pulmonary infections, and the remaining 10 children were normal and were assigned to the control group. results serum ada levels were higher in the pulmonary tb patients than in the control group (p < 0.05), however, these levels did not differ significantly between tb patients and patients with other pulmonary infections (p = 0.391). our evaluation revealed that ada level in tb patients with a positive smear of gastric washing were higher than those in patients with a negative smear (p = 0.006). conclusions similar to the other studies, this study showed higher serum ada level in pulmonary tb patients than in normal individuals. however, ada was not found to be a suitable marker for differentiating between pulmonary tb and other pulmonary infections.
منابع مشابه
diagnostic value of serum adenosine deaminase level in pulmonary tuberculosis
normal 0 false false false en-us x-none ar-sa background: in some studies, the level of adenosine deaminase ( ada) in sputum and effusion liquids was used for the diagnosis of tuberculosis (tb). but it is not always possible to access these materials. the goal of this study is to assess the diagnostic value of serum ada levels in pulmonary tb patients. materials and methods: in this study, 40 s...
متن کاملDiagnostic value of serum adenosine deaminase level in pulmonary tuberculosis
BACKGROUND In some studies, the level of adenosine deaminase (ADA) in sputum and effusion liquids was used for the diagnosis of tuberculosis (TB). But it is not always possible to access these materials. The goal of this study is to assess the diagnostic value of serum ADA levels in pulmonary TB patients. MATERIALS AND METHODS In this study, 40 sputum smear-positive TB patients who were hospi...
متن کاملdiagnostic value of serum adenosine deaminase (ada) level for pulmonary tuberculosis
conclusions serum ada activity with high specificity percentage may be a useful alternative test in restricted resource areas to rule out diagnosis of ptb. however, serum ada activity is not a useful tool for tb diagnosis. mean serum ada level in the ptb group was clearly higher than the mean serum ada in the other three groups. mean serum ada was 26 iu/l in ptb patients, 19.48 iu/l in patients...
متن کاملDiagnostic Value of Serum Adenosine Deaminase (ADA) Level for Pulmonary Tuberculosis
BACKGROUND Diagnosis of tuberculosis (TB) is not always easy, thus employing methods with a short duration and acceptable sensitivity and specificity is necessary to diagnose TB. OBJECTIVES The aim of this study was to investigate the diagnostic value of serum adenosine deaminase (ADA) level for diagnosis of pulmonary tuberculosis. PATIENTS AND METHODS A total of 160 sex and age-matched sub...
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Introduction: About one third of the world's population is infected with tuberculosis (TB) and each year, about 1.5 to 2 million people die from TB. Procalcitonin (PCT) is an inflammatory marker that its level has variable Materials and Methods: This conducted on patients with pulmonary TB. Data were collected using a check list. The serum level of PCT was measured by ELISA test at the beginnin...
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عنوان ژورنال:
journal of comprehensive pediatricsجلد ۳، شماره ۱، صفحات ۳-۶
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